Bos taurus Gene: PDHA1
Summary
InnateDB Gene IDBG-638610.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDHA1
Gene Name Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Synonyms PDHA;
Species Bos taurus
Ensembl Gene ENSBTAG00000019852
Encoded Proteins
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131828:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:130874454-130897343
Strand Reverse strand
Band
Transcripts
ENSBTAT00000057115 ENSBTAP00000052439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004738 pyruvate dehydrogenase activity
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016491 oxidoreductase activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006096 glycolytic process
GO:0006099 tricarboxylic acid cycle
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0043231 intracellular membrane-bounded organelle
GO:0045254 pyruvate dehydrogenase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of pyruvate dehydrogenase (PDH) complex pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Pyruvate metabolism pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Pyruvate metabolism pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Regulation of pyruvate dehydrogenase (PDH) complex pathway
Metabolism pathway
Pyruvate metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Citrate cycle (TCA cycle) pathway
Pyruvate metabolism pathway
Glycolysis / Gluconeogenesis pathway
Citrate cycle (TCA cycle) pathway
Pyruvate metabolism pathway
INOH
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt A7MB35
TrEMBL Q9N1X8
UniProt Splice Variant
Entrez Gene 407109
UniGene Bt.19415
RefSeq NM_001101046
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF132072 BC151313
GenPept AAF36517 AAI51314
RNA Seq Atlas 407109