InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDHA1

Summary

InnateDB Protein

IDBP-690697.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDHA1

Protein Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Synonyms

PDHA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000052439

InnateDB Gene

IDBG-638610 (PDHA1)

Protein Structure

UniProt Annotation

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004738	pyruvate dehydrogenase activity
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016491	oxidoreductase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006096	glycolytic process
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0043231	intracellular membrane-bounded organelle
GO:0045254	pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001017 Dehydrogenase, E1 component
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MB35

PhosphoSite