Version 5.4
Bos taurus Gene: DENND1A
Summary
InnateDB Gene IDBG-638649.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1A
Gene Name DENN domain-containing protein 1A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003610
Encoded Proteins
IDBP-690736
DENN/MADD domain containing 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119522:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94526960-95055931
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061512 ENSBTAP00000053496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006897 endocytosis
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
GO:0048488 synaptic vesicle endocytosis
Cellular Component
GO:0030136 clathrin-coated vesicle
GO:0030425 dendrite
GO:0030665 clathrin-coated vesicle membrane
GO:0043025 neuronal cell body
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119522
View Gene Order
ENSMUSG00000035392
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.6348
RefSeq NM_001193014
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca