Bos taurus Gene: PPP2R3A
Summary
InnateDB Gene IDBG-638716.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R3A
Gene Name serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Synonyms PPP2R3A;
Species Bos taurus
Ensembl Gene ENSBTAG00000023416
Encoded Proteins
protein phosphatase 2, regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit B'', alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073711:
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\'\' family. The B\'\' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B\'\'. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:134223427-134394973
Strand Reverse strand
Band
Transcripts
ENSBTAT00000031908 ENSBTAP00000031854
ENSBTAT00000011215 ENSBTAP00000011215
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001754 eye photoreceptor cell differentiation
GO:0007525 somatic muscle development
GO:0045732 positive regulation of protein catabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090249 regulation of cell motility involved in somitogenic axis elongation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
KEGG
mRNA surveillance pathway pathway
mRNA surveillance pathway pathway
INOH
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E1BIU6
UniProt Splice Variant
Entrez Gene 787607
UniGene Bt.104689 Bt.66280
RefSeq XM_005201921 XM_005195983 XM_005200222 XM_005201922
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003010 DAAA02003011 DAAA02003012
GenPept
RNA Seq Atlas 100851082 787607
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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