Homo sapiens Gene: PPP2R3A
Summary
InnateDB Gene IDBG-57743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R3A
Gene Name protein phosphatase 2, regulatory subunit B'', alpha
Synonyms PPP2R3; PR130; PR72;
Species Homo sapiens
Ensembl Gene ENSG00000073711
Encoded Proteins
protein phosphatase 2, regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit B'', alpha
protein phosphatase 2, regulatory subunit B'', alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\'\' family. The B\'\' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B\'\'. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:135965673-136147891
Strand Forward strand
Band q22.2
Transcripts
ENST00000264977 ENSP00000264977
ENST00000334546 ENSP00000334748
ENST00000447251 ENSP00000400980
ENST00000490467 ENSP00000419344
ENST00000469270
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0001754 eye photoreceptor cell differentiation
GO:0006470 protein dephosphorylation
GO:0007525 somatic muscle development
GO:0045732 positive regulation of protein catabolic process
GO:0050790 regulation of catalytic activity
GO:0061053 somite development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090249 regulation of cell motility involved in somitogenic axis elongation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
mRNA surveillance pathway pathway
INOH
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F6URX5
UniProt Splice Variant
Entrez Gene 5523
UniGene Hs.518155 Hs.644781 Hs.705580
RefSeq NM_001190447 NM_002718 NM_181897 XM_006713686
HUGO HGNC:9307
OMIM 604944
CCDS CCDS3087 CCDS3088 CCDS54642
HPRD 09225
IMGT
EMBL AC072039 AC092991
GenPept
RNA Seq Atlas 5523