Version 5.4
Homo sapiens Gene: PPP2R3A
Summary
InnateDB Gene IDBG-57743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R3A
Gene Name protein phosphatase 2, regulatory subunit B'', alpha
Synonyms PPP2R3; PR130; PR72
Species Homo sapiens
Ensembl Gene ENSG00000073711
Encoded Proteins
IDBP-57745
protein phosphatase 2, regulatory subunit B'', alpha
IDBP-57747
protein phosphatase 2, regulatory subunit B'', alpha
IDBP-384372
protein phosphatase 2, regulatory subunit B'', alpha
IDBP-476842
protein phosphatase 2, regulatory subunit B'', alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\'\' family. The B\'\' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B\'\'. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:135965673-136147891
Strand Forward strand
Band q22.2
Transcripts
ENST00000264977 ENSP00000264977
ENST00000334546 ENSP00000334748
ENST00000447251 ENSP00000400980
ENST00000490467 ENSP00000419344
ENST00000469270
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0001754 eye photoreceptor cell differentiation
GO:0006470 protein dephosphorylation
GO:0007525 somatic muscle development
GO:0045732 positive regulation of protein catabolic process
GO:0050790 regulation of catalytic activity
GO:0061053 somite development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090249 regulation of cell motility involved in somitogenic axis elongation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043154
View Gene Order
ENSBTAG00000023416
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518155 Hs.644781 Hs.705580
RefSeq NM_001190447 NM_002718 NM_181897 XM_006713686
HUGO
OMIM
CCDS CCDS3087 CCDS3088 CCDS54642
HPRD 09225
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca