InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GATA1

Summary

InnateDB Gene

IDBG-63880.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GATA1

Gene Name

GATA binding protein 1 (globin transcription factor 1)

Synonyms

ERYF1; GATA-1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT

Species

Homo sapiens

Ensembl Gene

ENSG00000102145

Encoded Proteins

IDBP-63882

GATA binding protein 1 (globin transcription factor 1)

IDBP-63884

GATA binding protein 1 (globin transcription factor 1)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:48786554-48794311

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000376670	ENSP00000365858
ENST00000376665	ENSP00000365853

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	61 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001158	enhancer sequence-specific DNA binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010559	regulation of glycoprotein biosynthetic process
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030220	platelet formation
GO:0030221	basophil differentiation
GO:0030222	eosinophil differentiation
GO:0030502	negative regulation of bone mineralization
GO:0033690	positive regulation of osteoblast proliferation
GO:0035162	embryonic hemopoiesis
GO:0035854	eosinophil fate commitment
GO:0043066	negative regulation of apoptotic process
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048821	erythrocyte development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527	platelet aggregation
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0097028	dendritic cell differentiation
GO:0097067	cellular response to thyroid hormone stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0017053	transcriptional repressor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031162

View Gene Order

ENSBTAG00000003184

Not yet available

Pathways

NETPATH

NetPath_15

IL3 pathway

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

hdac_classi_pathway

Signaling events mediated by HDAC Class I

hes_heypathway

Notch-mediated HES/HEY network

hdac_classii_pathway

Signaling events mediated by HDAC Class II

p73pathway

p73 transcription factor network

cmyb_pathway

C-MYB transcription factor network

Cross-References

SwissProt

P15976

TrEMBL

B7WNQ9

UniProt Splice Variant

Entrez Gene

2623

UniGene

Hs.765

RefSeq

NM_002049

HUGO

HGNC:4170

OMIM

305371

CCDS

CCDS14305

HPRD

IMGT

EMBL

AF196971 BC009797 CH471224 M30601 X17254

GenPept

AAA35885 AAH09797 CAA35120 EAW50749

RNA Seq Atlas

2623