Homo sapiens Gene: GATA1
Summary
InnateDB Gene IDBG-63880.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA1
Gene Name GATA binding protein 1 (globin transcription factor 1)
Synonyms ERYF1; GATA-1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT;
Species Homo sapiens
Ensembl Gene ENSG00000102145
Encoded Proteins
GATA binding protein 1 (globin transcription factor 1)
GATA binding protein 1 (globin transcription factor 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48786554-48794311
Strand Forward strand
Band p11.23
Transcripts
ENST00000376670 ENSP00000365858
ENST00000376665 ENSP00000365853
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 61 [view]
Protein-DNA 13 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008301 DNA binding, bending
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030221 basophil differentiation
GO:0030222 eosinophil differentiation
GO:0030502 negative regulation of bone mineralization
GO:0033690 positive regulation of osteoblast proliferation
GO:0035162 embryonic hemopoiesis
GO:0035854 eosinophil fate commitment
GO:0043066 negative regulation of apoptotic process
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0048821 erythrocyte development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527 platelet aggregation
GO:0071733 transcriptional activation by promoter-enhancer looping
GO:0097028 dendritic cell differentiation
GO:0097067 cellular response to thyroid hormone stimulus
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL3 pathway
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
Hemoglobins chaperone [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Notch-mediated HES/HEY network
Signaling events mediated by HDAC Class II
p73 transcription factor network
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL B7WNQ9
UniProt Splice Variant
Entrez Gene 2623
UniGene Hs.765
RefSeq NM_002049
HUGO HGNC:4170
OMIM 305371
CCDS CCDS14305
HPRD 02372
IMGT
EMBL AF196971 CH471224
GenPept EAW50749
RNA Seq Atlas 2623