InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRAF1

Summary

InnateDB Gene

IDBG-638832.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAF1

Gene Name

TNF receptor-associated factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003012

Encoded Proteins

IDBP-690931

TNF receptor-associated factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19698991

[Homo sapiens] TRAF1 is a positive regulator of the NF-kappaB alternative pathway.

PMID 19540595

[Homo sapiens] TRAF1 mediates both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents lymphoma cells from spontaneous and induced apoptosis.

PMID 18429822

[Homo sapiens] TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000056558:
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:112194564-112214586

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000043659

ENSBTAP00000041215

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.

Predicted by orthology
Total	97 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0031996	thioesterase binding

Biological Process

GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:2001236	regulation of extrinsic apoptotic signaling pathway