Homo sapiens Gene: TRAF1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-83153.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | TRAF1 | ||||||||||||||||||||||
Gene Name | TNF receptor-associated factor 1 | ||||||||||||||||||||||
Synonyms | EBI6; MGC:10353 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000056558 | ||||||||||||||||||||||
Encoded Proteins |
TNF receptor-associated factor 1
TNF receptor-associated factor 1
TNF receptor-associated factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
TRAF1 is a positive regulator of the NF-kappaB alternative pathway.
TRAF1 mediates both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents lymphoma cells from spontaneous and induced apoptosis.
TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
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Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:120902393-120929173 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q33.2 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
TNFalpha pathway
RANKL pathway
TWEAK pathway
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REACTOME | |||||||||||||||||||||||
KEGG |
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI |
CD40/CD40L signaling
TNF receptor signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Cross-References | |||||||||||||||||||||||
SwissProt | Q13077 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 7185 | ||||||||||||||||||||||
UniGene | Hs.531251 | ||||||||||||||||||||||
RefSeq | NM_001190945 NM_001190947 NM_005658 | ||||||||||||||||||||||
HUGO | HGNC:12031 | ||||||||||||||||||||||
OMIM | 601711 | ||||||||||||||||||||||
CCDS | CCDS55335 CCDS6825 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC006430 AK090468 AK295959 AK315476 AL832989 BC024145 BT019408 CH471090 U19261 | ||||||||||||||||||||||
GenPept | AAA62309 AAH24145 AAV38215 BAC03449 BAG37860 BAG58739 CAH56343 EAW87479 | ||||||||||||||||||||||
RNA Seq Atlas | 7185 | ||||||||||||||||||||||