Homo sapiens Gene: TRAF1
Summary
InnateDB Gene IDBG-83153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF1
Gene Name TNF receptor-associated factor 1
Synonyms EBI6; MGC:10353;
Species Homo sapiens
Ensembl Gene ENSG00000056558
Encoded Proteins
TNF receptor-associated factor 1
TNF receptor-associated factor 1
TNF receptor-associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRAF1 is a positive regulator of the NF-kappaB alternative pathway.
TRAF1 mediates both the CD30 signaling-dependent and independent NF-kappaB activation, which prevents lymphoma cells from spontaneous and induced apoptosis.
TRAF1 phosphorylation by the ubiquitously expressed kinase PKN1 plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:120902393-120929173
Strand Reverse strand
Band q33.2
Transcripts
ENST00000373887 ENSP00000362994
ENST00000540010 ENSP00000443183
ENST00000546084 ENSP00000438583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 124 [view]
Protein-Protein 122 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
Biological Process
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
RANKL pathway
TWEAK pathway
REACTOME
KEGG
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Tnfr2 signaling pathway [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
PID NCI
CD40/CD40L signaling
TNF receptor signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt Q13077
TrEMBL
UniProt Splice Variant
Entrez Gene 7185
UniGene Hs.531251
RefSeq NM_001190945 NM_001190947 NM_005658
HUGO HGNC:12031
OMIM 601711
CCDS CCDS55335 CCDS6825
HPRD
IMGT
EMBL AC006430 AK090468 AK295959 AK315476 AL832989 BC024145 BT019408 CH471090 U19261
GenPept AAA62309 AAH24145 AAV38215 BAC03449 BAG37860 BAG58739 CAH56343 EAW87479
RNA Seq Atlas 7185