InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BMX

Summary

InnateDB Gene

IDBG-638917.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMX

Gene Name

cytoplasmic tyrosine-protein kinase BMX

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000377

Encoded Proteins

IDBP-691036

BMX non-receptor tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18025155

[Homo sapiens] A tyrosine protein kinase that regulates TLR4 induced IL6 in macrophages independent of MAPK14 (p38-alpha) and NF-kappaB

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102010:
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:135201710-135238777

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000488

ENSBTAP00000000488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation