Version 5.4
Bos taurus Gene: PIGA
Summary
InnateDB Gene IDBG-638943.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGA
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007646
Encoded Proteins
IDBP-691055
phosphatidylinositol glycan anchor biosynthesis, class A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165195:
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:135421261-135430737
Strand Forward strand
Band
Transcripts
ENSBTAT00000010060 ENSBTAP00000010060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0009058 biosynthetic process
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165195
View Gene Order
ENSMUSG00000031381
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_243945
Synthesis of glycosylphosphatidylinositol (GPI) pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B7B9
UniProt Splice Variant
Entrez Gene 100139601
UniGene
RefSeq XM_002700395 XM_003584350
HUGO HGNC:8957
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02074886
GenPept
RNA Seq Atlas 100139601

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca