Bos taurus Gene: DHCR24
Summary
InnateDB Gene IDBG-639033.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHCR24
Gene Name delta(24)-sterol reductase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004688
Encoded Proteins
24-dehydrocholesterol reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] DHCR24 (Seladin1) is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. DHCR24 is an LPS-responsible gene product that negatively regulates the LPS-induced inflammatory response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116133:
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:91981619-92014282
Strand Forward strand
Band
Transcripts
ENSBTAT00000006153 ENSBTAP00000006153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899 enzyme binding
GO:0042605 peptide antigen binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0008203 cholesterol metabolic process
GO:0009888 tissue development
GO:0016125 sterol metabolic process
GO:0030539 male genitalia development
GO:0031639 plasminogen activation
GO:0042987 amyloid precursor protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588 skin development
GO:0055114 oxidation-reduction process
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
KEGG
Steroid biosynthesis pathway
Steroid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.106930
RefSeq NM_001103276
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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