InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DHCR24

Summary

InnateDB Gene

IDBG-639033.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHCR24

Gene Name

delta(24)-sterol reductase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004688

Encoded Proteins

IDBP-691152

24-dehydrocholesterol reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20406300

[Homo sapiens] DHCR24 (Seladin1) is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. DHCR24 is an LPS-responsible gene product that negatively regulates the LPS-induced inflammatory response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116133:
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:91981619-92014282

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006153

ENSBTAP00000006153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899	enzyme binding
GO:0042605	peptide antigen binding
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006979	response to oxidative stress
GO:0008104	protein localization
GO:0008203	cholesterol metabolic process
GO:0009888	tissue development
GO:0016125	sterol metabolic process
GO:0030539	male genitalia development
GO:0031639	plasminogen activation
GO:0042987	amyloid precursor protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588	skin development
GO:0055114	oxidation-reduction process
GO:0061024	membrane organization