|Homo sapiens Gene: DHCR24|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||24-dehydrocholesterol reductase|
|Synonyms||DCE; Nbla03646; seladin-1; SELADIN1;|
|Useful resources||Stemformatics EHFPI ImmGen|
DHCR24 (Seladin1) is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. DHCR24 is an LPS-responsible gene product that negatively regulates the LPS-induced inflammatory response.
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 1:54849633-54887218|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Steroid biosynthesis pathway
|UniProt Splice Variant|
|RNA Seq Atlas|