Homo sapiens Gene: DHCR24
Summary
InnateDB Gene IDBG-99054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHCR24
Gene Name 24-dehydrocholesterol reductase
Synonyms DCE; Nbla03646; seladin-1; SELADIN1;
Species Homo sapiens
Ensembl Gene ENSG00000116133
Encoded Proteins
24-dehydrocholesterol reductase
24-dehydrocholesterol reductase
24-dehydrocholesterol reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
DHCR24 (Seladin1) is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS. DHCR24 is an LPS-responsible gene product that negatively regulates the LPS-induced inflammatory response.
Entrez Gene
Summary This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:54849633-54887218
Strand Reverse strand
Band p32.3
Transcripts
ENST00000371269 ENSP00000360316
ENST00000436604 ENSP00000416585
ENST00000535035 ENSP00000440191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008762 UDP-N-acetylmuramate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0019899 enzyme binding
GO:0042605 peptide antigen binding
GO:0050614 delta24-sterol reductase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007050 cell cycle arrest
GO:0007265 Ras protein signal transduction
GO:0008104 protein localization
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0009888 tissue development
GO:0016125 sterol metabolic process
GO:0030539 male genitalia development
GO:0031639 plasminogen activation
GO:0042987 amyloid precursor protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043588 skin development
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0055114 oxidation-reduction process
GO:0061024 membrane organization
GO:1901214 regulation of neuron death
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Metabolism pathway
KEGG
Steroid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498727 Hs.608811
RefSeq NM_014762
HUGO
OMIM
CCDS CCDS600
HPRD 05916
IMGT
EMBL
GenPept
RNA Seq Atlas