Bos taurus Gene: TMPRSS3
Summary
InnateDB Gene IDBG-639428.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS3
Gene Name transmembrane protease serine 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021280
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160183:
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:144222210-144243229
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028354 ENSBTAP00000028354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0017080 sodium channel regulator activity
Biological Process
GO:0006508 proteolysis
GO:0006883 cellular sodium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007605 sensory perception of sound
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F1MYZ1
UniProt Splice Variant
Entrez Gene 537914
UniGene Bt.112379
RefSeq NM_001192926
HUGO HGNC:11877
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003293
GenPept
RNA Seq Atlas 537914