Version 5.4
Mus musculus Gene: Tmprss3
Summary
InnateDB Gene IDBG-163886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmprss3
Gene Name transmembrane protease, serine 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024034
Encoded Proteins
IDBP-163888
transmembrane protease, serine 3
IDBP-251533
transmembrane protease, serine 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160183:
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31179272-31198975
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000024833 ENSMUSP00000024833
ENSMUST00000114549 ENSMUSP00000110196
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
Biological Process
GO:0006508 proteolysis
GO:0006883 cellular sodium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007605 sensory perception of sound
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000160183
View Gene Order
ENSBTAG00000021280
Not yet available
Cross-References
SwissProt Q8K1T0
TrEMBL
UniProt Splice Variant
Entrez Gene 140765
UniGene Mm.214638
RefSeq NM_080727 NM_001163776 XM_006523636 XM_006523637
OMIM
CCDS CCDS37547 CCDS50053
HPRD
IMGT
MGI ID MGI:2155445
MGI Symbol Tmprss3
EMBL AJ300738 AJ429216 AY261383
GenPept AAO33581 CAC83350 CAD22137
RNA Seq Atlas 140765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca