Bos taurus Gene: TRPM2
Summary
InnateDB Gene IDBG-639705.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021901
Encoded Proteins
transient receptor potential cation channel, subfamily M, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response. (Demonstrated in murine model)
[Homo sapiens] TRPM2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation. (Demonstrated in mice)
[Mus musculus] Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response.
[Mus musculus] Trpm2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation in mice.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142185:
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:145830610-145871792
Strand Forward strand
Band
Transcripts
ENSBTAT00000029198 ENSBTAP00000029198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0016787 hydrolase activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006828 manganese ion transport
GO:0008152 metabolic process
GO:0033194 response to hydroperoxide
GO:0055085 transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
TRP channels pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
TRP channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E1BFK7
UniProt Splice Variant
Entrez Gene 508029
UniGene Bt.21130
RefSeq XM_002685138 XM_005195999 XM_005196000 XM_005202045 XM_005202046 XM_584750
HUGO HGNC:12339
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003440
GenPept
RNA Seq Atlas 508029
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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