InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRPM2

Summary

InnateDB Gene

IDBG-639705.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPM2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021901

Encoded Proteins

IDBP-691964

transient receptor potential cation channel, subfamily M, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21709234

[Homo sapiens] Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response. (Demonstrated in murine model)

PMID 22101731

[Homo sapiens] TRPM2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation. (Demonstrated in mice)

PMID 21709234

[Mus musculus] Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response.

PMID 22101731

[Mus musculus] Trpm2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation in mice.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142185:
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:145830610-145871792

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029198

ENSBTAP00000029198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005384	manganese ion transmembrane transporter activity
GO:0016787	hydrolase activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006828	manganese ion transport
GO:0008152	metabolic process
GO:0033194	response to hydroperoxide
GO:0055085	transmembrane transport
GO:0071421	manganese ion transmembrane transport