Homo sapiens Gene: TRPM2
Summary
InnateDB Gene IDBG-5302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM2
Gene Name transient receptor potential cation channel, subfamily M, member 2
Synonyms EREG1; KNP3; LTRPC2; NUDT9H; NUDT9L1; TRPC7;
Species Homo sapiens
Ensembl Gene ENSG00000142185
Encoded Proteins
transient receptor potential cation channel, subfamily M, member 2
transient receptor potential cation channel, subfamily M, member 2
transient receptor potential cation channel, subfamily M, member 2
transient receptor potential cation channel, subfamily M, member 2
transient receptor potential cation channel, subfamily M, member 2
transient receptor potential cation channel, subfamily M, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response. (Demonstrated in murine model)
TRPM2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Trpm2 deficient mice are extremely susceptible to infection with Listeria monocytogenes, exhibiting an inefficient innate immune response.
[Mus musculus] Trpm2 inhibits reactive oxygen species (ROS) production in phagocytic cells and prevents endotoxin-induced lung inflammation in mice.
Entrez Gene
Summary The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44350163-44443081
Strand Forward strand
Band q22.3
Transcripts
ENST00000300482 ENSP00000300482
ENST00000300481 ENSP00000300481
ENST00000397932 ENSP00000381026
ENST00000397928 ENSP00000381023
ENST00000431901 ENSP00000393982
ENST00000498430
ENST00000490982
ENST00000621064 ENSP00000477514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0016787 hydrolase activity
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0008152 metabolic process
GO:0033194 response to hydroperoxide
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0045087 innate immune response (InnateDB)
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
TRP channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003307 XM_005261171 XM_006724050
HUGO
OMIM
CCDS CCDS13710
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas