Version 5.4
Bos taurus Gene: ITGAV
Summary
InnateDB Gene IDBG-639711.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGAV
Gene Name integrin alpha-V precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019929
Encoded Proteins
IDBP-691915
integrin alpha-V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23150579
[Homo sapiens] ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138448:
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:9651631-9760100
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026553 ENSBTAP00000026553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001846 opsonin binding
GO:0005080 protein kinase C binding
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0031994 insulin-like growth factor I binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0030335 positive regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0032369 negative regulation of lipid transport
GO:0033690 positive regulation of osteoblast proliferation
GO:0043277 apoptotic cell clearance
GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785 positive regulation of cell adhesion
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050764 regulation of phagocytosis
GO:0070371 ERK1 and ERK2 cascade
GO:0070588 calcium ion transmembrane transport
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000425 regulation of apoptotic cell clearance
GO:2000536 negative regulation of entry of bacterium into host cell
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138448
View Gene Order
ENSMUSG00000027087
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111174
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_12519
PECAM1 interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_163942
Syndecan interactions pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_169262
Laminin interactions pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_604
Hemostasis pathway
REACT_196644
Syndecan interactions pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_227951
Signaling by VEGF pathway
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_202342
Laminin interactions pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_199093
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05200
Pathways in cancer pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04145
Phagosome pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04512
ECM-receptor interaction pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
avb3_integrin_pathway
Integrins in angiogenesis
integrin_cs_pathway
Integrin family cell surface interactions
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
nectin_pathway
Nectin adhesion pathway
fak_pathway
Signaling events mediated by focal adhesion kinase
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
integrin3_pathway
Beta3 integrin cell surface interactions
pdgfrapathway
PDGFR-alpha signaling pathway
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
pdgfrbpathway
PDGFR-beta signaling pathway
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL F1N1A9 Q8MKD4
UniProt Splice Variant
Entrez Gene 281875
UniGene Bt.5273
RefSeq NM_174367 XM_005202252
HUGO HGNC:6150
OMIM
CCDS
HPRD
IMGT
EMBL AF506751 DAAA02003964 DAAA02003965 DAAA02003966 DAAA02003967
GenPept AAM33400
RNA Seq Atlas 281875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca