InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGAV

Summary

InnateDB Gene

IDBG-77054.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAV

Gene Name

integrin, alpha V

Synonyms

CD51; MSK8; VNRA; VTNR

Species

Homo sapiens

Ensembl Gene

ENSG00000138448

Encoded Proteins

IDBP-77056

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

IDBP-77058

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

IDBP-387926

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

IDBP-387928

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23150579

ITGAV::ITGB3 is a sensor and activator of innate immunity to herpes simplex virus-1.

Entrez Gene

Summary

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:186590065-186680901

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000261023	ENSP00000261023
ENST00000374907	ENSP00000364042
ENST00000433736	ENSP00000404291
ENST00000430709	ENSP00000389442
ENST00000460641
ENST00000496477
ENST00000496854
ENST00000474571

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001846	opsonin binding
GO:0005080	protein kinase C binding
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0031994	insulin-like growth factor I binding
GO:0046872	metal ion binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0009615	response to virus
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010888	negative regulation of lipid storage
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031589	cell-substrate adhesion
GO:0032369	negative regulation of lipid transport
GO:0033690	positive regulation of osteoblast proliferation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043277	apoptotic cell clearance
GO:0045087	innate immune response (InnateDB)
GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785	positive regulation of cell adhesion
GO:0046718	viral entry into host cell
GO:0050748	negative regulation of lipoprotein metabolic process
GO:0050764	regulation of phagocytosis
GO:0050900	leukocyte migration
GO:0052066	entry of symbiont into host cell by promotion of host phagocytosis
GO:0070371	ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000425	regulation of apoptotic cell clearance
GO:2000536	negative regulation of entry of bacterium into host cell
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome