Bos taurus Gene: BT.21055 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-639894.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | BT.21055 | ||||||||||||||||||
Gene Name | MAP kinase-interacting serine/threonine-protein kinase 1 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000019933 | ||||||||||||||||||
Encoded Proteins |
MAP kinase-interacting serine/threonine-protein kinase 1
MAP kinase-interacting serine/threonine-protein kinase 1
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||
Summary |
[Homo sapiens] MKNK1 plays an important role in IFNG induced IRF1 expression and is essential for generation of anti-proliferative responses.
[Mus musculus] Mknk1 plays an important role in Ifng induced Irf1 expression and is essential for generation of anti-proliferation responses.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079277:
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 3:100126262-100172587 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH |
IL2 pathway
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REACTOME |
Spry regulation of FGF signaling pathway
Negative regulation of FGFR signaling pathway
Signaling by FGFR pathway
Signaling by FGFR in disease pathway
Signal Transduction pathway
Disease pathway
Disease pathway
Signaling by FGFR in disease pathway
Negative regulation of FGFR signaling pathway
Spry regulation of FGF signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
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KEGG |
MAPK signaling pathway pathway
Insulin signaling pathway pathway
Insulin signaling pathway pathway
MAPK signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI |
Signaling mediated by p38-alpha and p38-beta
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | F1N1A8 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 525647 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_001035358 XM_005204753 XM_005204754 | ||||||||||||||||||
HUGO | HGNC:7110 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | DAAA02008992 DAAA02008993 DAAA02008994 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 525647 | ||||||||||||||||||