Version 5.4
Homo sapiens Gene: MKNK1
Summary
InnateDB Gene IDBG-98137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKNK1
Gene Name MAP kinase interacting serine/threonine kinase 1
Synonyms MNK1
Species Homo sapiens
Ensembl Gene ENSG00000079277
Encoded Proteins
IDBP-98139
MAP kinase interacting serine/threonine kinase 1
IDBP-98143
MAP kinase interacting serine/threonine kinase 1
IDBP-98145
MAP kinase interacting serine/threonine kinase 1
IDBP-98147
MAP kinase interacting serine/threonine kinase 1
IDBP-383555
MAP kinase interacting serine/threonine kinase 1
IDBP-591366
MAP kinase interacting serine/threonine kinase 1
IDBP-597922
MAP kinase interacting serine/threonine kinase 1
IDBP-589589
MAP kinase interacting serine/threonine kinase 1
IDBP-583807
MAP kinase interacting serine/threonine kinase 1
IDBP-588260
MAP kinase interacting serine/threonine kinase 1
IDBP-598000
MAP kinase interacting serine/threonine kinase 1
IDBP-587386
MAP kinase interacting serine/threonine kinase 1
IDBP-586172
MAP kinase interacting serine/threonine kinase 1
IDBP-587634
MAP kinase interacting serine/threonine kinase 1
IDBP-592948
MAP kinase interacting serine/threonine kinase 1
IDBP-603232
MAP kinase interacting serine/threonine kinase 1
IDBP-599147
MAP kinase interacting serine/threonine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21149447
MKNK1 plays an important role in IFNG induced IRF1 expression and is essential for generation of anti-proliferative responses.
InnateDB Annotation from Orthologs
Summary
PMID 21149447
[Mus musculus] Mknk1 plays an important role in Ifng induced Irf1 expression and is essential for generation of anti-proliferation responses.
Entrez Gene
Summary This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:46557408-46616843
Strand Reverse strand
Band p33
Transcripts
ENST00000342571 ENSP00000339197
ENST00000371946 ENSP00000361014
ENST00000371945 ENSP00000361013
ENST00000341183 ENSP00000339573
ENST00000428112 ENSP00000411135
ENST00000470237
ENST00000460098
ENST00000496619 ENSP00000436709
ENST00000484301
ENST00000486716
ENST00000480531
ENST00000465783 ENSP00000434834
ENST00000474868 ENSP00000432369
ENST00000477883
ENST00000468852
ENST00000524749 ENSP00000435069
ENST00000528077 ENSP00000433038
ENST00000532897
ENST00000530528
ENST00000531355 ENSP00000434493
ENST00000524417
ENST00000532783 ENSP00000431837
ENST00000528237 ENSP00000432665
ENST00000526513 ENSP00000434051
ENST00000529170 ENSP00000435163
ENST00000531769 ENSP00000434021
ENST00000532110 ENSP00000431985
ENST00000525888
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 38 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0006468 protein phosphorylation
GO:0008152 metabolic process
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009651 response to salt stress
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028708
View Gene Order
ENSBTAG00000019933
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_111080
Spry regulation of FGF signaling pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_9470
Signaling by FGFR pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371594
RefSeq NM_001135553 NM_003684 NM_198973 XM_006711000 XM_006711001 XM_006711002 XM_006711003 XM_006711004 XM_006711005 XM_006711012 XM_006711013 XM_006711014 XM_006711015
HUGO
OMIM
CCDS CCDS30705 CCDS44134 CCDS538
HPRD 09468
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca