Bos taurus Gene: MCM8
Summary
InnateDB Gene IDBG-639895.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM8
Gene Name DNA replication licensing factor MCM8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014623
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125885:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48489739-48532765
Strand Forward strand
Band
Transcripts
ENSBTAT00000019471 ENSBTAP00000019471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007292 female gamete generation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0048232 male gamete generation
Cellular Component
GO:0005634 nucleus
GO:0097362 MCM8-MCM9 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
E2F-enabled inhibition of pre-replication complex formation pathway
S Phase pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
E2F mediated regulation of DNA replication pathway
Synthesis of DNA pathway
Cell Cycle pathway
Unwinding of DNA pathway
CDC6 association with the ORC:origin complex pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
DNA strand elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.45185
RefSeq NM_001193036
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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