Version 5.4
Bos taurus Gene: MCM8
Summary
InnateDB Gene IDBG-639895.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM8
Gene Name DNA replication licensing factor MCM8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014623
Encoded Proteins
IDBP-692092
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125885:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:48489739-48532765
Strand Forward strand
Band
Transcripts
ENSBTAT00000019471 ENSBTAP00000019471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007292 female gamete generation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0048232 male gamete generation
Cellular Component
GO:0005634 nucleus
GO:0097362 MCM8-MCM9 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000125885
View Gene Order
ENSMUSG00000027353
View Gene Order
Pathways
NETPATH
REACTOME
REACT_222889
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_225014
S Phase pathway
REACT_206368
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_207739
DNA Replication Pre-Initiation pathway
REACT_213604
DNA Replication pathway
REACT_215677
Assembly of the pre-replicative complex pathway
REACT_211609
G1/S Transition pathway
REACT_212671
Regulation of DNA replication pathway
REACT_213030
Orc1 removal from chromatin pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_201998
E2F mediated regulation of DNA replication pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_219301
Unwinding of DNA pathway
REACT_223713
CDC6 association with the ORC:origin complex pathway
REACT_226955
M/G1 Transition pathway
REACT_206537
G2/M Checkpoints pathway
REACT_221628
Activation of the pre-replicative complex pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_205537
Removal of licensing factors from origins pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_222483
Switching of origins to a post-replicative state pathway
REACT_203054
DNA strand elongation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_6776
Unwinding of DNA pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_244558
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_232628
DNA Replication pathway
REACT_217374
Unwinding of DNA pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_204269
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt E1BPX4
TrEMBL
UniProt Splice Variant
Entrez Gene 507507
UniGene Bt.45185
RefSeq NM_001193036
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036045
GenPept
RNA Seq Atlas 507507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca