Homo sapiens Gene: MCM8
Summary
InnateDB Gene IDBG-51957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM8
Gene Name minichromosome maintenance complex component 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125885
Encoded Proteins
minichromosome maintenance complex component 8
minichromosome maintenance complex component 8
minichromosome maintenance complex component 8
minichromosome maintenance complex component 8
minichromosome maintenance complex component 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:5950652-5995894
Strand Forward strand
Band p12.3
Transcripts
ENST00000378896 ENSP00000368174
ENST00000378886 ENSP00000368164
ENST00000265187 ENSP00000265187
ENST00000378883 ENSP00000368161
ENST00000610722 ENSP00000478141
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 cellular response to DNA damage stimulus
GO:0007292 female gamete generation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0048232 male gamete generation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0097362 MCM8-MCM9 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597484 Hs.669370 Hs.721004
RefSeq NM_001281520 NM_001281521 NM_001281522 NM_032485 NM_182802 XM_005260859
HUGO
OMIM
CCDS CCDS13094 CCDS13095 CCDS63226 CCDS63227
HPRD 12186
IMGT
EMBL
GenPept
RNA Seq Atlas