InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCM8

Summary

InnateDB Gene

IDBG-51957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM8

Gene Name

minichromosome maintenance complex component 8

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000125885

Encoded Proteins

IDBP-51959

minichromosome maintenance complex component 8

IDBP-51961

minichromosome maintenance complex component 8

IDBP-51963

minichromosome maintenance complex component 8

IDBP-51965

minichromosome maintenance complex component 8

IDBP-811503

minichromosome maintenance complex component 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:5950652-5995894

Strand

Forward strand

Band

p12.3

Transcripts

ENST00000378896	ENSP00000368174
ENST00000378886	ENSP00000368164
ENST00000265187	ENSP00000265187
ENST00000378883	ENSP00000368161
ENST00000610722	ENSP00000478141

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000724	double-strand break repair via homologous recombination
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006974	cellular response to DNA damage stimulus
GO:0007292	female gamete generation
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0048232	male gamete generation