Version 5.4
Bos taurus Gene: SMOX
Summary
InnateDB Gene IDBG-639998.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMOX
Gene Name spermine oxidase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001112
Encoded Proteins
IDBP-692211
spermine oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088826:
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51409995-51445203
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001472 ENSBTAP00000001472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
Biological Process
GO:0046208 spermine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000088826
View Gene Order
ENSMUSG00000027333
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_253147
Metabolism of polyamines pathway
REACT_243153
Interconversion of polyamines pathway
REACT_232343
Biological oxidations pathway
REACT_260206
PAOs oxidise polyamines to amines pathway
REACT_231002
Amine Oxidase reactions pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00410
beta-Alanine metabolism pathway
mmu00410
beta-Alanine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B7M5
UniProt Splice Variant
Entrez Gene 527211
UniGene Bt.106802
RefSeq NM_001205439
HUGO HGNC:15862
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036171
GenPept
RNA Seq Atlas 527211

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca