Mus musculus Gene: Smox | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-207112.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Smox | ||||||||||||||
Gene Name | spermine oxidase | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Gene | ENSMUSG00000027333 | ||||||||||||||
Encoded Proteins |
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
spermine oxidase
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088826:
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 2:131491496-131525922 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | F1 | ||||||||||||||
Transcripts | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Phase 1 - Functionalization of compounds pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism of polyamines pathway
Interconversion of polyamines pathway
Biological oxidations pathway
PAOs oxidise polyamines to amines pathway
Amine Oxidase reactions pathway
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KEGG |
beta-Alanine metabolism pathway
Arginine and proline metabolism pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME | |||||||||||||||
KEGG |
Arginine and proline metabolism pathway
beta-Alanine metabolism pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q99K82 | ||||||||||||||
TrEMBL | A2ANQ3 A2AP08 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 228608 | ||||||||||||||
UniGene | Mm.136586 | ||||||||||||||
RefSeq | NM_001177833 XM_006499287 XM_006499288 XM_006499289 XM_006499290 XM_006499292 NM_001177834 NM_001177835 NM_001177836 NM_001177837 NM_001177838 NM_001177839 NM_001177840 NM_145533 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS50719 CCDS16763 CCDS50718 CCDS50720 CCDS50721 CCDS50722 CCDS50723 CCDS50724 CCDS50725 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
MGI ID | MGI:2445356 | ||||||||||||||
MGI Symbol | Smox | ||||||||||||||
EMBL | AF495851 AF495852 AF495853 AF498364 AJ567473 AJ567474 AJ567475 AJ567476 AJ567477 AJ567478 AJ567479 AJ567480 AL831731 AL831781 BC004831 | ||||||||||||||
GenPept | AAH04831 AAN32908 AAN32909 AAN32910 AAN32915 CAD98866 CAD98867 CAD98868 CAD98869 CAD98870 CAD98871 CAD98872 CAD98873 CAM20374 CAM20375 CAM20376 CAM20378 CAM20379 CAM24528 CAM24529 CAM24530 CAM24531 CAM24532 | ||||||||||||||
RNA Seq Atlas | 228608 | ||||||||||||||