Version 5.4
Mus musculus Gene: Smox
Summary
InnateDB Gene IDBG-207112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smox
Gene Name spermine oxidase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027333
Encoded Proteins
IDBP-207114
spermine oxidase
IDBP-260797
spermine oxidase
IDBP-260799
spermine oxidase
IDBP-260801
spermine oxidase
IDBP-260805
spermine oxidase
IDBP-260807
spermine oxidase
IDBP-260809
spermine oxidase
IDBP-260811
spermine oxidase
IDBP-260813
spermine oxidase
IDBP-538926
spermine oxidase
IDBP-541718
spermine oxidase
IDBP-789314
spermine oxidase
IDBP-789315
spermine oxidase
IDBP-789319
spermine oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088826:
Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131491496-131525922
Strand Forward strand
Band F1
Transcripts
ENSMUST00000028806 ENSMUSP00000028806
ENSMUST00000110189 ENSMUSP00000105818
ENSMUST00000110188 ENSMUSP00000105817
ENSMUST00000110186 ENSMUSP00000105815
ENSMUST00000110183 ENSMUSP00000105812
ENSMUST00000110182 ENSMUSP00000105811
ENSMUST00000110181 ENSMUSP00000105810
ENSMUST00000110180 ENSMUSP00000105809
ENSMUST00000110179 ENSMUSP00000105808
ENSMUST00000129143 ENSMUSP00000120237
ENSMUST00000151627
ENSMUST00000131698 ENSMUSP00000114956
ENSMUST00000149180
ENSMUST00000151143
ENSMUST00000183575 ENSMUSP00000139099
ENSMUST00000183947 ENSMUSP00000139278
ENSMUST00000183881 ENSMUSP00000139111
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052894 norspermine:oxygen oxidoreductase activity
GO:0052895 N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity
Biological Process
GO:0046208 spermine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000088826
View Gene Order
ENSBTAG00000001112
Not yet available
Pathways
NETPATH
REACTOME
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_253147
Metabolism of polyamines pathway
REACT_243153
Interconversion of polyamines pathway
REACT_232343
Biological oxidations pathway
REACT_260206
PAOs oxidise polyamines to amines pathway
REACT_231002
Amine Oxidase reactions pathway
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00410
beta-Alanine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q99K82
TrEMBL A2ANQ3 A2AP08
UniProt Splice Variant
Entrez Gene 228608
UniGene Mm.136586
RefSeq NM_001177833 XM_006499287 XM_006499288 XM_006499289 XM_006499290 XM_006499292 NM_001177834 NM_001177835 NM_001177836 NM_001177837 NM_001177838 NM_001177839 NM_001177840 NM_145533
OMIM
CCDS CCDS50719 CCDS16763 CCDS50718 CCDS50720 CCDS50721 CCDS50722 CCDS50723 CCDS50724 CCDS50725
HPRD
IMGT
MGI ID MGI:2445356
MGI Symbol Smox
EMBL AF495851 AF495852 AF495853 AF498364 AJ567473 AJ567474 AJ567475 AJ567476 AJ567477 AJ567478 AJ567479 AJ567480 AL831731 AL831781 BC004831
GenPept AAH04831 AAN32908 AAN32909 AAN32910 AAN32915 CAD98866 CAD98867 CAD98868 CAD98869 CAD98870 CAD98871 CAD98872 CAD98873 CAM20374 CAM20375 CAM20376 CAM20378 CAM20379 CAM24528 CAM24529 CAM24530 CAM24531 CAM24532
RNA Seq Atlas 228608

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca