InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HOXD13

Summary

InnateDB Gene

IDBG-640382.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXD13

Gene Name

Uncharacterized protein

Synonyms

HOXD13

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004313

Encoded Proteins

IDBP-692645

homeobox D13

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128714:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5\' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:20854099-20856159

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005651

ENSBTAP00000005651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0022612	gland morphogenesis
GO:0030326	embryonic limb morphogenesis
GO:0030539	male genitalia development
GO:0035108	limb morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060571	morphogenesis of an epithelial fold
GO:0060602	branch elongation of an epithelium
GO:0060687	regulation of branching involved in prostate gland morphogenesis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000128714

View Gene Order

ENSMUSG00000001819

View Gene Order

Cross-References

SwissProt

TrEMBL

F1MT63

UniProt Splice Variant

Entrez Gene

100336775

UniGene

Bt.32614

RefSeq

XM_005197441

HUGO

HGNC:5136

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02004174 DAAA02004175

GenPept

RNA Seq Atlas

100336775