Bos taurus Gene: BT.26255
Summary
InnateDB Gene IDBG-640482.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.26255
Gene Name thrombopoietin receptor precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003781
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117400:
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:103247671-103261435
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004921 ENSBTAP00000004921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0032642 regulation of chemokine production
GO:0048872 homeostasis of number of cells
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
Hemostasis pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
TPO signaling pathway
JAK STAT pathway and regulation pathway
TPO signaling pathway
PID BIOCARTA
Tpo signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL C9E1C0 F1MX79
UniProt Splice Variant
Entrez Gene 528492
UniGene Bt.26255
RefSeq NM_001192663
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009047 GQ449246
GenPept ACV83923
RNA Seq Atlas 528492