Homo sapiens Gene: MPL
Summary
InnateDB Gene IDBG-97403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPL
Gene Name myeloproliferative leukemia virus oncogene
Synonyms C-MPL; CD110; MPLV; THCYT2; TPOR;
Species Homo sapiens
Ensembl Gene ENSG00000117400
Encoded Proteins
myeloproliferative leukemia virus oncogene
myeloproliferative leukemia virus oncogene
MPL proto-oncogene, thrombopoietin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43337807-43352772
Strand Forward strand
Band p34.2
Transcripts
ENST00000372470 ENSP00000361548
ENST00000413998 ENSP00000414004
ENST00000612993 ENSP00000480273
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0032642 regulation of chemokine production
GO:0048872 homeostasis of number of cells
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
TPO signaling pathway
PID BIOCARTA
Tpo signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P40238
TrEMBL Q5JUY5
UniProt Splice Variant
Entrez Gene 4352
UniGene Hs.82906
RefSeq NM_005373
HUGO HGNC:7217
OMIM 159530
CCDS CCDS483
HPRD
IMGT
EMBL AL139289 CH471059 M90102 M90103 U68159 U68160 U68161 U68162
GenPept AAA69971 AAA69972 AAB08424 AAB08425 CAI23380 EAX07103 EAX07105
RNA Seq Atlas 4352