Version 5.4
Bos taurus Gene: HTRA1
Summary
InnateDB Gene IDBG-640576.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTRA1
Gene Name Serine protease HTRA1
Synonyms PRSS11
Species Bos taurus
Ensembl Gene ENSBTAG00000008389
Encoded Proteins
IDBP-692956
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166033:
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:42659876-42716633
Strand Forward strand
Band
Transcripts
ENSBTAT00000011042 ENSBTAP00000011042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0019838 growth factor binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006508 proteolysis
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166033
View Gene Order
ENSMUSG00000006205
View Gene Order
Cross-References
SwissProt F1N152
TrEMBL
UniProt Splice Variant
Entrez Gene 282326
UniGene Bt.1613
RefSeq NM_001244233 XM_005225797
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF097707 DAAA02059453 DAAA02059454
GenPept AAC95151
RNA Seq Atlas 282326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca