InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HTRA1

Summary

InnateDB Protein

IDBP-692956.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTRA1

Protein Name

Uncharacterized protein

Synonyms

PRSS11;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011042

InnateDB Gene

IDBG-640576 (HTRA1)

Protein Structure

UniProt Annotation

Function

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0019838	growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006508	proteolysis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR001254 Peptidase S1
IPR001478 PDZ domain
IPR001940 Peptidase S1C
IPR002350 Kazal domain
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00219
PF00089
PF00595
PF13180
PF00050
PF07648

PRINTS

PR00834

PIRSF

SMART

SM00121
SM00020
SM00228
SM00280

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

F1N152

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282326

UniGene

Bt.1613

RefSeq

NP_001231162

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF097707 DAAA02059453 DAAA02059454

GenPept

AAC95151