Version 5.4
| Bos taurus Gene: SCYE1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-640591.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | SCYE1 | ||||||||||
| Gene Name | aminoacyl tRNA synthase complex-interacting multifunctional protein 1 | ||||||||||
| Synonyms | p43; SCYE1 | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000004230 | ||||||||||
| Encoded Proteins |
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] AIMP1 is phosphorylated by JNK through the TLR-MyD88 pathway, leading to the loss of its regulatory activity for endoplasmic reticulum retention of gp96 and resulting in the increase of cell surface expression of gp96, thus providing a new molecular mechanism underlying TLR-mediated gp96 regulation.
[Mus musculus] Aimp1 is a pleiotropic cytokine expressed in the salivary glands, small intestine and large intestine. Aimp1 not only induces the maturation and activation of bone marrow-derived dendritic cells, but also induces the expression of Tlr1, 2, 3 and 7.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164022:
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 6:20111150-20138597 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | Q3ZBX5 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 505126 | ||||||||||
| UniGene | Bt.49323 | ||||||||||
| RefSeq | NM_001035018 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC103049 DAAA02016657 | ||||||||||
| GenPept | AAI03050 | ||||||||||
| RNA Seq Atlas | 505126 | ||||||||||