Version 5.4
Homo sapiens Gene: AIMP1
Summary
InnateDB Gene IDBG-33233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIMP1
Gene Name aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms EMAP2; EMAPII; HLD3; p43; SCYE1
Species Homo sapiens
Ensembl Gene ENSG00000164022
Encoded Proteins
IDBP-33235
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
IDBP-241051
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
IDBP-375577
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
IDBP-475467
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20510162
AIMP1 is phosphorylated by JNK through the TLR-MyD88 pathway, leading to the loss of its regulatory activity for endoplasmic reticulum retention of gp96 and resulting in the increase of cell surface expression of gp96, thus providing a new molecular mechanism underlying TLR-mediated gp96 regulation.
InnateDB Annotation from Orthologs
Summary
PMID 21711348
[Mus musculus] Aimp1 is a pleiotropic cytokine expressed in the salivary glands, small intestine and large intestine. Aimp1 not only induces the maturation and activation of bone marrow-derived dendritic cells, but also induces the expression of Tlr1, 2, 3 and 7.
Entrez Gene
Summary The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:106315544-106349226
Strand Forward strand
Band q24
Transcripts
ENST00000358008 ENSP00000350699
ENST00000394701 ENSP00000378191
ENST00000442366 ENSP00000405248
ENST00000510207 ENSP00000423681
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 42 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006006 glucose metabolic process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009611 response to wounding
GO:0010467 gene expression
GO:0016192 vesicle-mediated transport
GO:0045087 innate immune response (InnateDB)
GO:0050900 leukocyte migration
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0009986 cell surface
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0030133 transport vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028029
View Gene Order
ENSBTAG00000004230
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q12904
TrEMBL D6R937
UniProt Splice Variant
Entrez Gene 9255
UniGene Hs.480465 Hs.591680
RefSeq NM_001142415 NM_001142416 NM_004757
HUGO HGNC:10648
OMIM 603605
CCDS CCDS3674 CCDS47121
HPRD
IMGT
EMBL AC093680 AK095951 AK303965 BC014051 CR542281 U10117
GenPept AAA62202 AAH14051 BAG53174 BAG64889 CAG47076
RNA Seq Atlas 9255

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca