Bos taurus Gene: MCM7
Summary
InnateDB Gene IDBG-640716.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM7
Gene Name DNA replication licensing factor MCM7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000030965
Encoded Proteins
DNA replication licensing factor MCM7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166508:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:36885892-36893315
Strand Forward strand
Band
Transcripts
ENSBTAT00000003728 ENSBTAP00000003728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.
Predicted by orthology
Total 102 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0042325 regulation of phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042555 MCM complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
S Phase pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
Cell Cycle pathway
Unwinding of DNA pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
DNA strand elongation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
KEGG
DNA replication pathway
Cell cycle pathway
DNA replication pathway
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
ATR signaling pathway
Cross-References
SwissProt Q3ZBH9
TrEMBL Q56JY6
UniProt Splice Variant
Entrez Gene 539924
UniGene Bt.49518
RefSeq NM_001025345 XM_005225185 XM_005225186
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY911341 BC103287
GenPept AAI03288 AAW82109
RNA Seq Atlas 539924
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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