Version 5.4
Bos taurus Gene: MCM7
Summary
InnateDB Gene IDBG-640716.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCM7
Gene Name DNA replication licensing factor MCM7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000030965
Encoded Proteins
IDBP-693010
DNA replication licensing factor MCM7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166508:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:36885892-36893315
Strand Forward strand
Band
Transcripts
ENSBTAT00000003728 ENSBTAP00000003728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.
Predicted by orthology
Total 102 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0042325 regulation of phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042555 MCM complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166508
View Gene Order
ENSMUSG00000029730
View Gene Order
Pathways
NETPATH
REACTOME
REACT_225014
S Phase pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_207739
DNA Replication Pre-Initiation pathway
REACT_213604
DNA Replication pathway
REACT_215677
Assembly of the pre-replicative complex pathway
REACT_211609
G1/S Transition pathway
REACT_212671
Regulation of DNA replication pathway
REACT_213030
Orc1 removal from chromatin pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_219301
Unwinding of DNA pathway
REACT_226955
M/G1 Transition pathway
REACT_206537
G2/M Checkpoints pathway
REACT_221628
Activation of the pre-replicative complex pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_205537
Removal of licensing factors from origins pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_222483
Switching of origins to a post-replicative state pathway
REACT_203054
DNA strand elongation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_6776
Unwinding of DNA pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_232628
DNA Replication pathway
REACT_217374
Unwinding of DNA pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
hsa03030
DNA replication pathway
hsa04110
Cell cycle pathway
mmu03030
DNA replication pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49518
RefSeq NM_001025345 XM_005225185 XM_005225186
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca