Mus musculus Gene: Mcm7
Summary
InnateDB Gene IDBG-205861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcm7
Gene Name minichromosome maintenance deficient 7 (S. cerevisiae)
Synonyms AI747533; mCDC47; Mcmd7;
Species Mus musculus
Ensembl Gene ENSMUSG00000029730
Encoded Proteins
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166508:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138164583-138172422
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000000505 ENSMUSP00000000505
ENSMUST00000148879 ENSMUSP00000116131
ENSMUST00000125316
ENSMUST00000142254
ENSMUST00000153867 ENSMUSP00000121566
ENSMUST00000139223
ENSMUST00000139983 ENSMUSP00000121446
ENSMUST00000155902 ENSMUSP00000120243
ENSMUST00000148094 ENSMUSP00000121344
ENSMUST00000147920 ENSMUSP00000116169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 107 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process
GO:0042325 regulation of phosphorylation
GO:0042493 response to drug
GO:0071310 cellular response to organic substance
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
KEGG
DNA replication pathway
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Unwinding of DNA pathway
Cell Cycle pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
S Phase pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
Cell Cycle pathway
Unwinding of DNA pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
DNA strand elongation pathway
KEGG
DNA replication pathway
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
ATR signaling pathway
Cross-References
SwissProt
TrEMBL D3Z0J6 D3Z335
UniProt Splice Variant
Entrez Gene 17220
UniGene Mm.378965 Mm.482227
RefSeq NM_008568 XM_006504556
OMIM
CCDS CCDS19793
HPRD
IMGT
MGI ID MGI:1298398
MGI Symbol Mcm7
EMBL AC151719
GenPept
RNA Seq Atlas 17220