Version 5.4
Bos taurus Gene: COPS6
Summary
InnateDB Gene IDBG-640726.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS6
Gene Name COP9 signalosome complex subunit 6
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002871
Encoded Proteins
IDBP-693020
COP9 signalosome complex subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168090:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:36893605-36896370
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003725 ENSBTAP00000003725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 258 interaction(s) predicted by orthology.
Predicted by orthology
Total 258 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0008180 COP9 signalosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000168090
View Gene Order
ENSMUSG00000019494
View Gene Order
Cross-References
SwissProt
TrEMBL F1MG10
UniProt Splice Variant
Entrez Gene 512756
UniGene
RefSeq NM_001101963
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058286
GenPept
RNA Seq Atlas 512756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca