InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.12647

Summary

InnateDB Gene

IDBG-640804.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.12647

Gene Name

mediator of RNA polymerase II transcription subunit 25

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008518

Encoded Proteins

IDBP-693111

mediator of RNA polymerase II transcription subunit 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104973:
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:56632968-56646924

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043183

ENSBTAP00000040773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042974	retinoic acid receptor binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0035563	positive regulation of chromatin binding
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048147	negative regulation of fibroblast proliferation
GO:0071158	positive regulation of cell cycle arrest
GO:2001178	positive regulation of mediator complex assembly