Version 5.4
Homo sapiens Gene: MED25
Summary
InnateDB Gene IDBG-63568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED25
Gene Name mediator complex subunit 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104973
Encoded Proteins
IDBP-63578
mediator complex subunit 25
IDBP-583119
mediator complex subunit 25
IDBP-766053
IDBP-760453
IDBP-811678
mediator complex subunit 25
IDBP-811679
mediator complex subunit 25
IDBP-811684
mediator complex subunit 25
IDBP-811688
mediator complex subunit 25
IDBP-811690
mediator complex subunit 25
IDBP-811695
mediator complex subunit 25
IDBP-811698
mediator complex subunit 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49818279-49838816
Strand Forward strand
Band q13.33
Transcripts
ENST00000312865 ENSP00000326767
ENST00000538643 ENSP00000437496
ENST00000599722
ENST00000593767 ENSP00000470692
ENST00000593636
ENST00000593595
ENST00000594998
ENST00000595185 ENSP00000470027
ENST00000620467 ENSP00000482659
ENST00000622402 ENSP00000478074
ENST00000612791 ENSP00000479851
ENST00000617849 ENSP00000484882
ENST00000618715 ENSP00000480731
ENST00000622046 ENSP00000483584
ENST00000612854 ENSP00000482155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 61 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042974 retinoic acid receptor binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008219 cell death
GO:0010467 gene expression
GO:0035563 positive regulation of chromatin binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048147 negative regulation of fibroblast proliferation
GO:0071158 positive regulation of cell cycle arrest
GO:2001178 positive regulation of mediator complex assembly
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002968
View Gene Order
ENSBTAG00000008518
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_030973
HUGO
OMIM
CCDS CCDS33075
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca