InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CANX

Summary

InnateDB Gene

IDBG-640982.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CANX

Gene Name

calnexin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000048107

Encoded Proteins

IDBP-693298

calnexin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127022:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:1506750-1538915

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064711

ENSBTAP00000054517

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0048488	synaptic vesicle endocytosis
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome