Version 5.4
Bos taurus Gene: DHRS9
Summary
InnateDB Gene IDBG-640997.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHRS9
Gene Name Dehydrogenase/reductase SDR family member 9
Synonyms RDHL
Species Bos taurus
Ensembl Gene ENSBTAG00000004557
Encoded Proteins
IDBP-693320
Dehydrogenase/reductase SDR family member 9
IDBP-693324
Dehydrogenase/reductase SDR family member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073737:
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27116745-27140610
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005986 ENSBTAP00000005986
ENSBTAT00000063743 ENSBTAP00000055524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0042448 progesterone metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031090 organelle membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000073737
View Gene Order
ENSMUSG00000027068
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
mmu00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q8HYR6
TrEMBL
UniProt Splice Variant
Entrez Gene 282851
UniGene Bt.12764
RefSeq NM_174733 XM_005202308
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF362071
GenPept AAN75756
RNA Seq Atlas 282851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca