Version 5.4
Homo sapiens Gene: DHRS9
Summary
InnateDB Gene IDBG-74381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHRS9
Gene Name dehydrogenase/reductase (SDR family) member 9
Synonyms 3-alpha-HSD; 3ALPHA-HSD; RDH-E2; RDH-TBE; RDH15; RDHL; RDHTBE; RETSDR8; SDR9C4
Species Homo sapiens
Ensembl Gene ENSG00000073737
Encoded Proteins
IDBP-74385
dehydrogenase/reductase (SDR family) member 9
IDBP-387320
dehydrogenase/reductase (SDR family) member 9
IDBP-387321
dehydrogenase/reductase (SDR family) member 9
IDBP-387323
dehydrogenase/reductase (SDR family) member 9
IDBP-387324
dehydrogenase/reductase (SDR family) member 9
IDBP-387325
dehydrogenase/reductase (SDR family) member 9
IDBP-387326
dehydrogenase/reductase (SDR family) member 9
IDBP-808199
dehydrogenase/reductase (SDR family) member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:169064789-169096167
Strand Forward strand
Band q31.1
Transcripts
ENST00000357546 ENSP00000350154
ENST00000428522 ENSP00000388564
ENST00000450153 ENSP00000391214
ENST00000421653 ENSP00000388066
ENST00000432060 ENSP00000389241
ENST00000436483 ENSP00000407167
ENST00000412271 ENSP00000407747
ENST00000602501 ENSP00000473337
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016854 racemase and epimerase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0002138 retinoic acid biosynthetic process
GO:0008152 metabolic process
GO:0008209 androgen metabolic process
GO:0030855 epithelial cell differentiation
GO:0042448 progesterone metabolic process
GO:0042572 retinol metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027068
View Gene Order
ENSBTAG00000004557
Not yet available
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001142270 NM_001142271 NM_001289763 NM_005771 NM_199204 XM_005246230
HUGO
OMIM
CCDS CCDS2231 CCDS74600
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca