Version 5.4
Bos taurus Gene: GRIN1
Summary
InnateDB Gene IDBG-641190.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047202
Encoded Proteins
IDBP-693560
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176884:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:105922299-105945800
Strand Reverse strand
Band
Transcripts
ENSBTAT00000065439 ENSBTAP00000056506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.
Predicted by orthology
Total 87 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102 receptor binding
GO:0005215 transporter activity
GO:0005216 ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016594 glycine binding
GO:0016595 glutamate binding
Biological Process
GO:0001661 conditioned taste aversion
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007585 respiratory gaseous exchange
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0008542 visual learning
GO:0010646 regulation of cell communication
GO:0018964 propylene metabolic process
GO:0019233 sensory perception of pain
GO:0021586 pons maturation
GO:0021987 cerebral cortex development
GO:0034220 ion transmembrane transport
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048814 regulation of dendrite morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050905 neuromuscular process
GO:0051963 regulation of synapse assembly
GO:0055074 calcium ion homeostasis
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176884
View Gene Order
ENSMUSG00000026959
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05016
Huntington's disease pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04720
Long-term potentiation pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu05016
Huntington's disease pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3N3K3
UniProt Splice Variant
Entrez Gene 100336579
UniGene
RefSeq XM_002691702
HUGO HGNC:4584
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032413 DAAA02032414 DAAA02032415
GenPept
RNA Seq Atlas 100336579
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca