Homo sapiens Gene: GRIN1
InnateDB Gene IDBG-93071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN1
Gene Name glutamate receptor, ionotropic, N-methyl D-aspartate 1
Synonyms GluN1; MRD8; NMDA1; NMDAR1; NR1;
Species Homo sapiens
Ensembl Gene ENSG00000176884
Encoded Proteins
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137138390-137168762
Strand Forward strand
Band q34.3
ENST00000371561 ENSP00000360616
ENST00000371559 ENSP00000360614
ENST00000371560 ENSP00000360615
ENST00000350902 ENSP00000316915
ENST00000371553 ENSP00000360608
ENST00000371550 ENSP00000360605
ENST00000371555 ENSP00000360610
ENST00000371546 ENSP00000360601
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102 receptor binding
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0019899 enzyme binding
GO:0022843 voltage-gated cation channel activity
GO:0035254 glutamate receptor binding
GO:0042165 neurotransmitter binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001661 conditioned taste aversion
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007268 synaptic transmission
GO:0007585 respiratory gaseous exchange
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0008542 visual learning
GO:0010646 regulation of cell communication
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0018964 propylene metabolic process
GO:0019233 sensory perception of pain
GO:0021586 pons maturation
GO:0021987 cerebral cortex development
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048511 rhythmic process
GO:0048814 regulation of dendrite morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050905 neuromuscular process
GO:0051262 protein tetramerization
GO:0051592 response to calcium ion
GO:0051963 regulation of synapse assembly
GO:0055074 calcium ion homeostasis
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060992 response to fungicide
GO:0071287 cellular response to manganese ion
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032590 dendrite membrane
GO:0043005 neuron projection
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097481 neuronal postsynaptic density
Mus musculus
Bos taurus
Gene ID
Gene Order
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Axon guidance pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Transmission across Chemical Synapses pathway
EPH-Ephrin signaling pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
CREB phosphorylation through the activation of CaMKII pathway
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
GPCR Dopamine D1like receptor signaling pathway pathway
Nitric oxide signaling pathway [Biocarta view]
UniProt Splice Variant
Entrez Gene 2902
UniGene Hs.671363
RefSeq NM_007327 NM_021569 NM_001185090 NM_000832 NM_001185091 XM_005266073 XM_005266072
OMIM 138249
CCDS CCDS7031 CCDS7032 CCDS55354 CCDS43910 CCDS55355
HPRD 15926
RNA Seq Atlas 2902