Homo sapiens Gene: GRIN1
Summary
InnateDB Gene IDBG-93071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIN1
Gene Name glutamate receptor, ionotropic, N-methyl D-aspartate 1
Synonyms GluN1; MRD8; NMDA1; NMDAR1; NR1;
Species Homo sapiens
Ensembl Gene ENSG00000176884
Encoded Proteins
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137138390-137168762
Strand Forward strand
Band q34.3
Transcripts
ENST00000371561 ENSP00000360616
ENST00000371559 ENSP00000360614
ENST00000371560 ENSP00000360615
ENST00000350902 ENSP00000316915
ENST00000371553 ENSP00000360608
ENST00000371550 ENSP00000360605
ENST00000371555 ENSP00000360610
ENST00000371546 ENSP00000360601
ENST00000471122
ENST00000485413
ENST00000460273
ENST00000473811
ENST00000462584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 80 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102 receptor binding
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0019899 enzyme binding
GO:0022843 voltage-gated cation channel activity
GO:0035254 glutamate receptor binding
GO:0042165 neurotransmitter binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001661 conditioned taste aversion
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007268 synaptic transmission
GO:0007585 respiratory gaseous exchange
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0008542 visual learning
GO:0010646 regulation of cell communication
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0018964 propylene metabolic process
GO:0019233 sensory perception of pain
GO:0021586 pons maturation
GO:0021987 cerebral cortex development
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048511 rhythmic process
GO:0048814 regulation of dendrite morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050905 neuromuscular process
GO:0051262 protein tetramerization
GO:0051592 response to calcium ion
GO:0051963 regulation of synapse assembly
GO:0055074 calcium ion homeostasis
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060992 response to fungicide
GO:0071287 cellular response to manganese ion
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032590 dendrite membrane
GO:0043005 neuron projection
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Axon guidance pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Transmission across Chemical Synapses pathway
EPH-Ephrin signaling pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
CREB phosphorylation through the activation of CaMKII pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
INOH
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
Nitric oxide signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2902
UniGene Hs.671363
RefSeq NM_007327 NM_021569 NM_001185090 NM_000832 NM_001185091 XM_005266073 XM_005266072
HUGO HGNC:4584
OMIM 138249
CCDS CCDS7031 CCDS7032 CCDS55354 CCDS43910 CCDS55355
HPRD 15926
IMGT
EMBL
GenPept
RNA Seq Atlas 2902