InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCK1

Summary

InnateDB Gene

IDBG-641267.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCK1

Gene Name

phosphoenolpyruvate carboxykinase, cytosolic

Synonyms

PPCK1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001936

Encoded Proteins

IDBP-693616

phosphoenolpyruvate carboxykinase, cytosolic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124253:
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:59144594-59150719

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000002520

ENSBTAP00000002520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding
GO:0030145	manganese ion binding
GO:0031406	carboxylic acid binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006475	internal protein amino acid acetylation
GO:0006629	lipid metabolic process
GO:0032868	response to insulin
GO:0046327	glycerol biosynthetic process from pyruvate