Version 5.4
Homo sapiens Gene: NPR2
Summary
InnateDB Gene IDBG-64127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPR2
Gene Name natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Synonyms AMDM; ANPb; ANPRB; ECDM; GUC2B; GUCY2B; NPRB; NPRBi
Species Homo sapiens
Ensembl Gene ENSG00000159899
Encoded Proteins
IDBP-64129
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
IDBP-368872
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
IDBP-368874
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
IDBP-368877
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35792154-35809732
Strand Forward strand
Band p13.3
Transcripts
ENST00000342694 ENSP00000341083
ENST00000421267 ENSP00000399204
ENST00000447210 ENSP00000393029
ENST00000448821 ENSP00000402902
ENST00000464810
ENST00000469249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016849 phosphorus-oxygen lyase activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
Biological Process
GO:0001503 ossification
GO:0006182 cGMP biosynthetic process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0008217 regulation of blood pressure
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
GO:0044702 single organism reproductive process
GO:0051447 negative regulation of meiotic cell cycle
GO:0060348 bone development
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1900194 negative regulation of oocyte maturation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000028469
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.78518
RefSeq NM_003995 XM_005251478
HUGO
OMIM
CCDS CCDS6590
HPRD 00166
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca