InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPR2

Summary

InnateDB Protein

IDBP-64129.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPR2

Protein Name

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)

Synonyms

AMDM; ANPb; ANPRB; ECDM; GUC2B; GUCY2B; NPRB; NPRBi;

Species

Homo sapiens

Ensembl Protein

ENSP00000341083

InnateDB Gene

IDBG-64127 (NPR2)

Protein Structure

UniProt Annotation

Function

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000269PubMed:15146390, ECO:0000269PubMed:1672777}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Acromesomelic dysplasia, Maroteaux type (AMDM) [MIM:602875]: An autosomal recessive acromesomelic chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. {ECO:0000269PubMed:15146390}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016849	phosphorus-oxygen lyase activity
GO:0016941	natriuretic peptide receptor activity
GO:0017046	peptide hormone binding
GO:0042562	hormone binding
GO:0042802	identical protein binding

Biological Process

GO:0001503	ossification
GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0008217	regulation of blood pressure
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0044702	single organism reproductive process
GO:0051447	negative regulation of meiotic cell cycle
GO:0060348	bone development
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001170 Natriuretic peptide receptor
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001828 Extracellular ligand-binding receptor
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028082 Periplasmic binding protein-like I
IPR029787 Nucleotide cyclase

PFAM

PF00069
PF00211
PF07714
PF01094

PRINTS

PR00255
PR00109

PIRSF

SMART

SM00044
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt