InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.44996

Summary

InnateDB Gene

IDBG-641612.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.44996

Gene Name

tyrosine-protein kinase HCK isoform 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007932

Encoded Proteins

IDBP-693995

hemopoietic cell kinase isoform 2

IDBP-693996

hemopoietic cell kinase isoform 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101336:
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:62106257-62151619

Strand

Forward strand

Band

Transcripts

ENSBTAT00000056914	ENSBTAP00000051020
ENSBTAT00000037322	ENSBTAP00000037156

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0050830	defense response to Gram-positive bacterium