InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hck

Summary

InnateDB Gene

IDBG-209984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hck

Gene Name

hemopoietic cell kinase

Synonyms

AI849071; Bmk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003283

Encoded Proteins

IDBP-209986

hemopoietic cell kinase

IDBP-261615

hemopoietic cell kinase

IDBP-790110

hemopoietic cell kinase

IDBP-790111

hemopoietic cell kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:153108468-153151441

Strand

Forward strand

Band

Transcripts

ENSMUST00000003370	ENSMUSP00000003370
ENSMUST00000109799	ENSMUSP00000105423
ENSMUST00000191431	ENSMUSP00000139988
ENSMUST00000189688	ENSMUSP00000141030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006887	exocytosis
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045087	innate immune response
GO:0046777	protein autophosphorylation
GO:0050764	regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium
GO:0071801	regulation of podosome assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005901	caveola
GO:0005925	focal adhesion
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0042995	cell projection