InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACVR1

Summary

InnateDB Gene

IDBG-641620.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR1

Gene Name

activin receptor type-1 precursor

Synonyms

ActR-IA; ACVR1A

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011909

Encoded Proteins

IDBP-694006

activin receptor type-1 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115170:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:39287889-39361498

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015797

ENSBTAP00000015797

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005025	transforming growth factor beta receptor activity, type I
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016361	activin receptor activity, type I
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0048185	activin binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001569	patterning of blood vessels
GO:0001701	in utero embryonic development
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0001755	neural crest cell migration
GO:0002526	acute inflammatory response
GO:0003143	embryonic heart tube morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003289	atrial septum primum morphogenesis
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007281	germ cell development
GO:0007368	determination of left/right symmetry
GO:0007369	gastrulation
GO:0007498	mesoderm development
GO:0007507	heart development
GO:0009968	negative regulation of signal transduction
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016310	phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030278	regulation of ossification
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051145	smooth muscle cell differentiation
GO:0060037	pharyngeal system development
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060923	cardiac muscle cell fate commitment
GO:0061445	endocardial cushion cell fate commitment
GO:2000017	positive regulation of determination of dorsal identity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0048179	activin receptor complex