Mus musculus Gene: Acvr1
InnateDB Gene IDBG-172102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acvr1
Gene Name activin A receptor, type 1
Synonyms ActR-I; ActRIA; Acvr; Acvrlk2; Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L;
Species Mus musculus
Ensembl Gene ENSMUSG00000026836
Encoded Proteins
activin A receptor, type 1
activin A receptor, type 1
activin A receptor, type 1
activin A receptor, type 1
activin A receptor, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115170:
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:58388644-58567157
Strand Reverse strand
Band C1.1
ENSMUST00000090935 ENSMUSP00000088453
ENSMUST00000056376 ENSMUSP00000056784
ENSMUST00000112601 ENSMUSP00000108220
ENSMUST00000112599 ENSMUSP00000108218
ENSMUST00000126407 ENSMUSP00000120755
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016361 activin receptor activity, type I
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0042803 protein homodimerization activity
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001569 patterning of blood vessels
GO:0001655 urogenital system development
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001707 mesoderm formation
GO:0001755 neural crest cell migration
GO:0002526 acute inflammatory response
GO:0003143 embryonic heart tube morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0006468 protein phosphorylation
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007281 germ cell development
GO:0007368 determination of left/right symmetry
GO:0007369 gastrulation
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0009968 negative regulation of signal transduction
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030278 regulation of ossification
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0045669 positive regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048641 regulation of skeletal muscle tissue development
GO:0051145 smooth muscle cell differentiation
GO:0060037 pharyngeal system development
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060923 cardiac muscle cell fate commitment
GO:0061445 endocardial cushion cell fate commitment
GO:0071385 cellular response to glucocorticoid stimulus
GO:2000017 positive regulation of determination of dorsal identity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0045177 apical part of cell
GO:0048179 activin receptor complex
Homo sapiens
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
BMP2 signaling pathway
TGF-beta signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
Pathway Predictions based on Human Orthology Data
Cytokine-cytokine receptor interaction pathway
TGF-beta signaling pathway pathway
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
ALK2 signaling events
ALK1 pathway
ALK1 signaling events
SwissProt P37172
UniProt Splice Variant
Entrez Gene 11477
UniGene Mm.394526 Mm.487720 Mm.689
RefSeq NM_001110204 NM_007394 NM_001110205 XM_006497622
MGI ID MGI:87911
MGI Symbol Acvr1
EMBL AF332087 AF332088 AK150014 AK150075 AL732468 AL772179 AL807788 BC058718 L15436
GenPept AAA40495 AAH58718 AAK56115 AAK56116 BAE29239 BAE29286
RNA Seq Atlas 11477