Homo sapiens Gene: P4HA3
Summary
InnateDB Gene IDBG-64210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HA3
Gene Name prolyl 4-hydroxylase, alpha polypeptide III
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149380
Encoded Proteins
prolyl 4-hydroxylase, alpha polypeptide III
prolyl 4-hydroxylase, alpha polypeptide III
prolyl 4-hydroxylase, alpha polypeptide III
prolyl 4-hydroxylase, alpha polypeptide III
prolyl 4-hydroxylase, alpha polypeptide III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74235801-74311657
Strand Reverse strand
Band q13.4
Transcripts
ENST00000331597 ENSP00000332170
ENST00000427714 ENSP00000401749
ENST00000540363
ENST00000524388 ENSP00000433860
ENST00000532689 ENSP00000431350
ENST00000525968 ENSP00000431227
ENST00000531716
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0019511 peptidyl-proline hydroxylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Arginine and proline metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660541 Hs.662590 Hs.733512
RefSeq NM_001288748 NM_182904 XM_005273924
HUGO
OMIM
CCDS CCDS73347 CCDS8230
HPRD 16413
IMGT
EMBL
GenPept
RNA Seq Atlas