Version 5.4
Bos taurus Gene: OSCAR
Summary
InnateDB Gene IDBG-642249.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSCAR
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001051
Encoded Proteins
IDBP-694685
osteoclast associated, immunoglobulin-like receptor
IDBP-694690
osteoclast associated, immunoglobulin-like receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170909:
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:63467220-63474744
Strand Forward strand
Band
Transcripts
ENSBTAT00000001395 ENSBTAP00000001395
ENSBTAT00000063567 ENSBTAP00000054591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000170909
View Gene Order
ENSMUSG00000054594
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_21
RANKL pathway
REACTOME
KEGG
hsa04380
Osteoclast differentiation pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1B8Y2 G3MYF9
UniProt Splice Variant
Entrez Gene 100336423
UniGene Bt.46333
RefSeq
HUGO HGNC:29960
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047818 DAAA02047819 DAAA02047820
GenPept
RNA Seq Atlas 100336423

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca